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Circular RNA mitochondrial translation optimization 1 correlates with less lymph node metastasis, longer disease‐free survival, and higher chemotherapy sensitivity in gastric cancer

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Circular‐mitochondrial translation optimization 1 (circ‐MTO1) inhibits the progression of gastric cancer by regulating the growth, apoptosis, and invasion of tumor cells. However, its clinical potential as a biomarker for gastric… Click to show full abstract

Circular‐mitochondrial translation optimization 1 (circ‐MTO1) inhibits the progression of gastric cancer by regulating the growth, apoptosis, and invasion of tumor cells. However, its clinical potential as a biomarker for gastric cancer remains to be further evaluated. This study aimed to assess circ‐MTO1 expression and its correlation with clinical features and prognosis in gastric cancer patients, as well as the effect of circ‐MTO1 on the sensitivity to chemotherapy in gastric cancer cells.

Keywords: translation optimization; mitochondrial translation; cancer; gastric cancer

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2022

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