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DNA testing for sickle cell anemia in Africa: Implementation choices for the Democratic Republic of Congo

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Hemoglobin‐based tests form the reference diagnostic test for SCA. In limited resource countries, these tests face limitations including cost, low sensitivity due to recurrent transfusions in endemic malaria region, and… Click to show full abstract

Hemoglobin‐based tests form the reference diagnostic test for SCA. In limited resource countries, these tests face limitations including cost, low sensitivity due to recurrent transfusions in endemic malaria region, and interference from fetal hemoglobin in neonatal diagnostic. This study aimed at adapting DNA‐based SCA tests to limited resource countries and evaluating the economic benefit.

Keywords: cell anemia; dna; anemia africa; testing sickle; dna testing; sickle cell

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2022

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