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Carbapenem antibiotic stress increases bla KPC ‐2 gene relative copy number and bacterial resistance levels of Klebsiella pneumoniae

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The clinical isolation rates of carbapenem‐resistant Klebsiella pneumoniae (CR‐KP) continue to increase. In China, clinical CR‐KP isolates are mainly attributed to the blaKPC‐2 gene carried on plasmids, and the blaKPC‐2… Click to show full abstract

The clinical isolation rates of carbapenem‐resistant Klebsiella pneumoniae (CR‐KP) continue to increase. In China, clinical CR‐KP isolates are mainly attributed to the blaKPC‐2 gene carried on plasmids, and the blaKPC‐2 copy number correlates with the expression of KPC enzymes, which can cause elevated carbapenem MICs.

Keywords: klebsiella pneumoniae; gene; carbapenem antibiotic; copy number

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2022

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