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Preanalytical DNA assessment for downstream applications: How to optimize the management of human biospecimens to support molecular diagnosis—An experimental study

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The development of next‐generation sequencing approaches has accelerated the diagnostic process, although at present, there is a lack of a clear consensus on efficient management of human samples for downstream… Click to show full abstract

The development of next‐generation sequencing approaches has accelerated the diagnostic process, although at present, there is a lack of a clear consensus on efficient management of human samples for downstream applications. This study aims to investigate timeframe (in terms of short preservation), temperature, and additional preservation procedures (i.e., freeze and thaw cycles) for human biospecimens to implement the reliability and reproducibility of molecular investigations.

Keywords: human biospecimens; preanalytical dna; downstream applications; management human

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2022

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