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Evaluating the utility of a two‐assay serological algorithm for hepatitis C screening in a low prevalence population

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Screening for hepatitis C virus (HCV) is performed by testing for anti‐HCV antibodies, which may yield false‐positive results leading to additional testing and other downstream consequences for the patient. We… Click to show full abstract

Screening for hepatitis C virus (HCV) is performed by testing for anti‐HCV antibodies, which may yield false‐positive results leading to additional testing and other downstream consequences for the patient. We report our experience in a low prevalence population (<0.05%) using a two‐assay algorithm aimed at testing specimens with borderline or weak positive anti‐HCV reactivity in the screening assay by a second anti‐HCV assay prior to confirming positive anti‐HCV results with RT‐PCR.

Keywords: low prevalence; prevalence population; anti hcv; hepatitis; two assay

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2023

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