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Soluble Fibrinogen–Like Protein 2 Downregulation and Th17/Treg Imbalance in a Taurocholate‐Induced Murine Experimental Model of Severe Acute Pancreatitis

Severe acute pancreatitis (SAP) is associated with tremendous systemic inflammation, T‐helper 17 (Th17) cells, and regulatory T (Treg) cells play an essential role in the inflammatory responses. Meanwhile, soluble fibrinogen–like… Click to show full abstract

Severe acute pancreatitis (SAP) is associated with tremendous systemic inflammation, T‐helper 17 (Th17) cells, and regulatory T (Treg) cells play an essential role in the inflammatory responses. Meanwhile, soluble fibrinogen–like protein 2 (Sfgl2) is a critical immunosuppressive effector cytokine of Treg cells and modulates immune responses. However, the impact of SAP induction on Sfgl2 expression and the role of Sfgl2 in immunomodulation under SAP conditions are largely unknown.

Keywords: like protein; fibrinogen like; soluble fibrinogen; treg; acute pancreatitis; severe acute

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2024

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