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Persistent AST Elevation in a Patient With Ovarian Cancer: A Rare Diagnostic Challenge

Persistent elevation of aspartate aminotransferase (AST) is commonly indicative of liver injury or disease, but isolated AST elevation without concurrent alanine aminotransferase (ALT) increase is rare and difficult to diagnose.… Click to show full abstract

Persistent elevation of aspartate aminotransferase (AST) is commonly indicative of liver injury or disease, but isolated AST elevation without concurrent alanine aminotransferase (ALT) increase is rare and difficult to diagnose. While AST is non‐specific and found in various tissues, its isolated elevation is due to less common conditions, such as macro‐AST, where AST binds with immunoglobulins creating a high‐molecular‐weight complex that affects serum activity.

Keywords: patient ovarian; elevation patient; elevation; ovarian cancer; persistent ast; ast elevation

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2025

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