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Accumulating evidences has shown that tumor suppressor candidate 7 (TUSC7) as a putatively tumor suppressor gene in various tumors. The low‐expression of TUSC7 is related to poor prognosis, and increased… Click to show full abstract
Accumulating evidences has shown that tumor suppressor candidate 7 (TUSC7) as a putatively tumor suppressor gene in various tumors. The low‐expression of TUSC7 is related to poor prognosis, and increased the proliferation rate of tumor cells. Over‐expression of TUSC7 could suppress tumor cell proliferation, migration, invasion, and colony formation, suggesting that TUSC7 might be a diagnostic and prognostic biomarker, as well as therapeutic target. In this review, we summarized the molecular mechanism and clinical significance of TUSC7 in tumorigenesis, tumor progression, and prognosis.
Journal Title: Journal of Cellular Physiology
Year Published: 2018
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