LAUSR

Interleukin‐34 (IL‐34) shares a common receptor with macrophage colony‐stimulating factor (M‐CSF), and can bind to CSF‐1R, induces lymphocytes differentiation, proliferation, and regulates the synthesis of inflammatory components. Recent findings reported aberrant expression of IL‐34 in several autoimmune disorders, such as lupus, arthritis, systemic sclerosis, inflammatory bowel diseases. The functional analysis further demonstrated that IL‐34 may perform significantly in these inflammatory autoimmune disorders. IL‐34 might consider as a biomarker for these diseases. I hope this collection of the findings in this review will improve knowledge of the role of IL‐34, and targeting IL‐34 may give the potential for these autoimmune diseases.