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Sirtuin 1 (SIRT1) is a NAD+ sensitive deacetylase that has been linked to longevity and has been suggested to confer beneficial effects that counter aging‐associated deterioration. Muscle repair is dependent… Click to show full abstract
Sirtuin 1 (SIRT1) is a NAD+ sensitive deacetylase that has been linked to longevity and has been suggested to confer beneficial effects that counter aging‐associated deterioration. Muscle repair is dependent upon satellite cell function, which is reported to be reduced with aging; however, it is not known if this is linked to an aging‐suppression of SIRT1. This study tested the hypothesis that Sirtuin 1 (SIRT1) overexpression would increase the extent of muscle repair and muscle function in older mice.
Keywords:
sirt1;
muscle;
older mice;
muscle function;
repair
Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2019
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Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!