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High levels of modified ceramides are a defining feature of murine and human cancer cachexia

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Cancer cachexia (CCx) is a multifactorial energy‐wasting syndrome reducing the efficiency of anti‐cancer therapies, quality of life, and survival of cancer patients. In the past years, most studies focused on… Click to show full abstract

Cancer cachexia (CCx) is a multifactorial energy‐wasting syndrome reducing the efficiency of anti‐cancer therapies, quality of life, and survival of cancer patients. In the past years, most studies focused on the identification of tumour and host‐derived proteins contributing to CCx. However, there is still a lack of studies addressing the changes in bioactive lipids. The aim of this study was to identify specific lipid species as a hallmark of CCx by performing a broad range lipid analysis of plasma from well‐established CCx mouse models as well as cachectic and weight stable cancer patients.

Keywords: high levels; modified ceramides; levels modified; cancer cachexia; cancer

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2020

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