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Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading

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Translational capacity (i.e. ribosomal mass) is a key determinant of protein synthesis and has been associated with skeletal muscle hypertrophy. The role of translational capacity in muscle atrophy and regrowth… Click to show full abstract

Translational capacity (i.e. ribosomal mass) is a key determinant of protein synthesis and has been associated with skeletal muscle hypertrophy. The role of translational capacity in muscle atrophy and regrowth from disuse is largely unknown. Therefore, we investigated the effect of muscle disuse and reloading on translational capacity in middle‐aged men (Study 1) and in rats (Study 2).

Keywords: translational capacity; muscle disuse; muscle; disuse reloading; capacity muscle

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2020

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