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Activated mast cells in skeletal muscle can be a potential mediator for cancer‐associated cachexia

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Eighty per cent of United States advanced cancer patients faces a worsened prognosis due to cancer‐associated cachexia. Inflammation is one driver of muscle atrophy in cachexia, and skeletal muscle‐resident immune… Click to show full abstract

Eighty per cent of United States advanced cancer patients faces a worsened prognosis due to cancer‐associated cachexia. Inflammation is one driver of muscle atrophy in cachexia, and skeletal muscle‐resident immune cells could be a source of inflammation. This study explores the efficacy of cancer activated skeletal muscle‐resident mast cells as a biomarker and mediator of cachexia.

Keywords: skeletal muscle; associated cachexia; muscle; mast cells; cancer; cancer associated

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2021

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