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Serum carnitine as a biomarker of sarcopenia and nutritional status in preoperative gastrointestinal cancer patients

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Sarcopenia is an important factor in the postoperative outcome of gastrointestinal cancer patients. However, little research has been carried out on potential biomarkers of sarcopenia. Carnitine is an amino acid… Click to show full abstract

Sarcopenia is an important factor in the postoperative outcome of gastrointestinal cancer patients. However, little research has been carried out on potential biomarkers of sarcopenia. Carnitine is an amino acid derivative that is stored in skeletal muscle and is essential for muscle energy metabolism. The primary purpose of this study was to investigate whether serum carnitine level is a biomarker of sarcopenia in preoperative patients with gastrointestinal cancer. The secondary purposes were (i) to examine the associations between carnitine, nutritional status, and albumin level, and (ii) to determine whether carnitine is a prognostic factor for postoperative complications.

Keywords: cancer; gastrointestinal cancer; nutritional status; serum carnitine; cancer patients; biomarker sarcopenia

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2021

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