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Most patients with pancreatic cancer develop cachexia, which is characterized by progressive muscle loss. The mechanisms underlying muscle loss in cancer cachexia remain elusive. Pancreatic tumour organoids are 3D cell… Click to show full abstract
Most patients with pancreatic cancer develop cachexia, which is characterized by progressive muscle loss. The mechanisms underlying muscle loss in cancer cachexia remain elusive. Pancreatic tumour organoids are 3D cell culture models that retain key characteristics of the parent tumour. We aimed to investigate the effect of pancreatic tumour organoid‐derived factors on processes that determine skeletal muscle mass, including the regulation of muscle protein turnover and myogenesis.
Keywords:
tumour organoid;
pancreatic tumour;
muscle;
tumour;
organoid derived;
derived factors
Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2022
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Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!