LAUSR

Intensive care unit (ICU)‐acquired weakness can persist beyond ICU stay and has been associated with long‐term functional impairment of ICU survivors. Recently, DNA methylation alterations were found in the blood of ICU patients, partially explaining long‐term developmental impairment of critically ill children. As illness‐induced aberrant DNA methylation theoretically could also be involved in long‐term weakness, we investigated whether the DNA methylation signature in muscle of adult critically ill patients differs from that in muscle of healthy controls.