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Lung cancer is the primary cause of cancer deaths worldwide. Activation of epidermal growth factor receptor (EGFR) leads to lung cancer progression and poor prognosis while involuntary weight loss remains… Click to show full abstract
Lung cancer is the primary cause of cancer deaths worldwide. Activation of epidermal growth factor receptor (EGFR) leads to lung cancer progression and poor prognosis while involuntary weight loss remains a major problem. Tumour‐derived parathyroid hormone‐related protein (PTHrP) emerged as a potential mediator of cachexia. Here, we investigated the modulatory role of EGFR signalling in PTHrP (encoded by Pthlh) gene expression and the impact of this relationship on cancer cachexia.
Keywords:
epidermal growth;
factor receptor;
parathyroid hormone;
growth factor;
cancer;
hormone related
Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2022
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Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!