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Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis

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Patients with multiple sclerosis (MS) experience reduced exercise tolerance that substantially reduces quality of life. The mechanisms underpinning exercise intolerance in MS are not fully clear. This study aimed to… Click to show full abstract

Patients with multiple sclerosis (MS) experience reduced exercise tolerance that substantially reduces quality of life. The mechanisms underpinning exercise intolerance in MS are not fully clear. This study aimed to determine the contributions of the cardiopulmonary system and peripheral muscle in MSā€induced exercise intolerance before and after exercise training.

Keywords: exercise training; muscle; multiple sclerosis; exercise; exercise tolerance

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2022

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