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The atypical β‐blocker S‐oxprenolol reduces cachexia and improves survival in a rat cancer cachexia model

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Beta‐blockers and selected stereoisomers of beta‐blockers, like bisoprolol and S‐pindolol (ACM‐001), have been shown to be effective in preclinical cancer cachexia models. Here, we tested the efficacy of stereoisomers of… Click to show full abstract

Beta‐blockers and selected stereoisomers of beta‐blockers, like bisoprolol and S‐pindolol (ACM‐001), have been shown to be effective in preclinical cancer cachexia models. Here, we tested the efficacy of stereoisomers of oxprenolol in two preclinical models of cancer cachexia—the Yoshida AH‐130 rat model and the Lewis lung carcinoma (LLC) mouse model.

Keywords: rat; cancer cachexia; atypical blocker; model; cancer

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2022

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