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Different effects of low muscle mass on the risk of non‐alcoholic fatty liver disease and hepatic fibrosis in a prospective cohort

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Non‐alcoholic fatty liver disease (NAFLD) and sarcopenia share insulin resistance as a common pathophysiology and have overlapping clinical manifestation of metabolic derangement; hence, it is difficult to differentiate the independent… Click to show full abstract

Non‐alcoholic fatty liver disease (NAFLD) and sarcopenia share insulin resistance as a common pathophysiology and have overlapping clinical manifestation of metabolic derangement; hence, it is difficult to differentiate the independent effect of sarcopenia on the development of NAFLD from concomitant metabolic disorders. Using a community‐based prospective cohort study, the contributions of low muscle mass and genetic risk factors to the development of NAFLD and NAFLD‐related hepatic fibrosis were investigated in the Korean population.

Keywords: alcoholic fatty; non alcoholic; fatty liver; muscle; prospective cohort; liver disease

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2022

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