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Resistance and endurance exercise training improves muscle mass and the inflammatory/fibrotic transcriptome in a rhabdomyosarcoma model

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Rhabdomyosarcoma (RMS) is an aggressive soft tissue sarcoma that most often develops in children. Chemoradiation therapy is a standard treatment modality; however, the detrimental long‐term skeletal muscle consequences of this… Click to show full abstract

Rhabdomyosarcoma (RMS) is an aggressive soft tissue sarcoma that most often develops in children. Chemoradiation therapy is a standard treatment modality; however, the detrimental long‐term skeletal muscle consequences of this therapy in juvenile cancer survivors include muscle atrophy and fibrosis resulting in decreased physical performance. Using a novel model of murine resistance and endurance exercise training, we investigate its role in preventing the long‐term effects of juvenile RMS plus therapy.

Keywords: endurance exercise; exercise training; model; resistance endurance; rhabdomyosarcoma

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2023

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