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Ghrelin is a potential therapy for cachexia due to its orexigenic properties and anabolic effects on muscle and fat. However, its clinical use is limited by the short half‐life of… Click to show full abstract
Ghrelin is a potential therapy for cachexia due to its orexigenic properties and anabolic effects on muscle and fat. However, its clinical use is limited by the short half‐life of active (acylated) ghrelin (~11 min in humans). EXT418 is a novel long‐acting, constitutively active ghrelin analog created by covalently linking it to a vitamin D derivative. Here, we evaluated the effects and mechanisms of action of EXT418 on Lewis lung carcinoma (LLC)‐induced cachexia in mice.
Keywords:
lung carcinoma;
ext418 novel;
novel long;
lewis lung;
ghrelin;
long acting
Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2023
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Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!