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Muscle stem cells contribute to long‐term tissue repletion following surgical sepsis

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Over the past decade, advances in sepsis identification and management have resulted in decreased sepsis mortality. This increase in survivorship has highlighted a new clinical obstacle: chronic critical illness (CCI),… Click to show full abstract

Over the past decade, advances in sepsis identification and management have resulted in decreased sepsis mortality. This increase in survivorship has highlighted a new clinical obstacle: chronic critical illness (CCI), for which there are no effective treatment options. Up to half of sepsis survivors suffer from CCI, which can include multi‐organ dysfunction, chronic inflammation, muscle wasting, physical and mental disabilities, and enhanced frailty. These symptoms prevent survivors from returning to regular day‐to‐day activities and are directly associated with poor quality of life.

Keywords: sepsis; muscle; contribute long; muscle stem; cells contribute; stem cells

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2023

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