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Evidence for inefficient contraction and abnormal mitochondrial activity in sarcopenia using magnetic resonance spectroscopy

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Mitochondrial dysfunction has been implicated in sarcopenia. 31P magnetic resonance spectroscopy (MRS) enables non‐invasive measurement of adenosine triphosphate (ATP) synthesis rates to probe mitochondrial function. Here, we assessed muscle energetics… Click to show full abstract

Mitochondrial dysfunction has been implicated in sarcopenia. 31P magnetic resonance spectroscopy (MRS) enables non‐invasive measurement of adenosine triphosphate (ATP) synthesis rates to probe mitochondrial function. Here, we assessed muscle energetics in older sarcopenic and non‐sarcopenic men and compared with muscle biopsy‐derived markers of mitochondrial function.

Keywords: magnetic resonance; resonance spectroscopy; spectroscopy; evidence inefficient; sarcopenia

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2023

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