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A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti‐Aging Mechanisms

Skeletal muscle function and mass continuously decrease during aging. Most studies target limb muscles owing to their direct impact on mobility and falls risk. The diaphragm (DIA), also a type… Click to show full abstract

Skeletal muscle function and mass continuously decrease during aging. Most studies target limb muscles owing to their direct impact on mobility and falls risk. The diaphragm (DIA), also a type of skeletal muscle with different phenotype, has received less attention. Comparative research of the DIA and limb muscles can reveal their distinct aging characteristics. Critically, the potential endogenous anti‐aging mechanisms of DIA that may provide new insights into the mechanisms of sarcopenia in limb muscles remain scarce.

Keywords: aging mechanisms; sarcopenia limb; limb; diaphragm; anti aging; limb muscles

Journal Title: Journal of Cachexia, Sarcopenia and Muscle
Year Published: 2025

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