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Benefits of hypothermia in neonatal arterial ischemic strokes: A preclinical study

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There is currently no targeted treatment available for neonatal arterial ischemic strokes (NAIS). Epidemiological studies demonstrated that perinatal infection/inflammation, peripartum hypoxia, and occlusion of the internal carotid tree are the… Click to show full abstract

There is currently no targeted treatment available for neonatal arterial ischemic strokes (NAIS). Epidemiological studies demonstrated that perinatal infection/inflammation, peripartum hypoxia, and occlusion of the internal carotid tree are the main determinants of NAIS. The well‐established benefit of therapeutic hypothermia (HT) in neonatal encephalopathy due to diffuse hypoxia‐ischemia provides a rationale for the potential use of HT as a neuroprotective strategy in NAIS.

Keywords: ischemic strokes; hypothermia neonatal; strokes preclinical; neonatal arterial; arterial ischemic; benefits hypothermia

Journal Title: International Journal of Developmental Neuroscience
Year Published: 2020

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