LAUSR

BACKGROUND Pancreatoduodenectomy (PD) is an only curative therapy for distal cholangiocarcinoma (dCC). There has been no study to compare outcomes between minimally invasive pancreatoduodenectomy (MIPD) and open pancreatoduodenectomy (OPD) for dCC. The aim of the study is to compare the two operation types for dCC in terms of postoperative and oncologic outcomes. METHODS Data from 426 patients who underwent MIPD (n=91) or OPD (n=335) for dCC from January 2012 to December 2019 at two tertiary hospitals were retrospectively reviewed. After 1:2 propensity score matching, postoperative and oncologic outcomes were compared. RESULTS MIPD group showed more favorable results than OPD group in terms of blood loss (MIPD vs. OPD, 250[150-400] vs. 400[200-600], ml, p<0.001), and length of hospital stay (19.8±11.3 vs. 26.6±14.3, days, p<0.001). OPD group showed more favorable results than MIPD group in terms of operation time (MIPD vs. OPD, 457±70 vs. 398±85, min., p<0.001), and harvested lymph nodes (14.9±7.8 vs. 20.7±11.5, p<0.001). There was no statistical difference between the 2 groups in the R0 resection rate and complications. In long-term survival analysis, there was no significant difference between the 2 groups. CONCLUSION MIPD showed comparable postoperative complications and long-term oncologic survival with OPD in the treatment of dCC.