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A simple, economical, and efficient approach to the one-pot synthesis of 3-methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones by multicomponent assembling of 5-methylpyrazol-3-amine, aldehydes, and Meldrum's acid using mesoporous silica phenylsulfonic acid (SBA-15-Ph-SO3H) as recyclable and… Click to show full abstract
A simple, economical, and efficient approach to the one-pot synthesis of 3-methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones by multicomponent assembling of 5-methylpyrazol-3-amine, aldehydes, and Meldrum's acid using mesoporous silica phenylsulfonic acid (SBA-15-Ph-SO3H) as recyclable and heterogonous solid acid nanocatalyst has been described. This protocol has the advantages of high yields, wide application scope, and an environmental benign procedure.
Journal Title: Journal of Heterocyclic Chemistry
Year Published: 2017
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