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Novel tricyclic 1,4-diazepine derivatives – pyrido[3′,2′:4,5]thieno[3,2-e][1,4]diazepin-2-ones – have been synthesized. Azetidin-2-one moiety has been incorporated into the 1,4-diazepine scaffold by [2 + 2]cycloaddition of functionalized ketenes to imine C═N bond, and several… Click to show full abstract
Novel tricyclic 1,4-diazepine derivatives – pyrido[3′,2′:4,5]thieno[3,2-e][1,4]diazepin-2-ones – have been synthesized. Azetidin-2-one moiety has been incorporated into the 1,4-diazepine scaffold by [2 + 2]cycloaddition of functionalized ketenes to imine C═N bond, and several tetracyclic azetodiazepines which can be considered as potential compounds of biological interest have been prepared. Stereoselectivity of the cycloaddition was proved by NMR and X-ray analysis data.
Journal Title: Journal of Heterocyclic Chemistry
Year Published: 2017
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