Photo by benchaccounting from unsplash
An efficient and environmentally benign protocol for the synthesis of indeno [2ˊ,1ˊ:5,6] pyrido[2,3-d] pyrimidines has been developed. The synthesis of these pharmacologically important compounds can be achieved by the one-pot… Click to show full abstract
An efficient and environmentally benign protocol for the synthesis of indeno [2ˊ,1ˊ:5,6] pyrido[2,3-d] pyrimidines has been developed. The synthesis of these pharmacologically important compounds can be achieved by the one-pot three-component condensation of 6-amino-1,3-dimethyluracil, aromatic aldehydes, and 1,3-indandione in ethanol without using catalyst and oxidizing agent. This protocol has the advantages of easier work-up, milder reaction conditions, and an environmentally benign procedure compared with other methods.
Journal Title: Journal of Heterocyclic Chemistry
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!