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Microwave-assisted three-component reactions of arylglyoxals with cyclic 1,3-dicarbonyl compounds and naphthalen-2-amine have been established, by which a series of new functionalized benzo[e]indoles with good yields were synthesized. The reaction was… Click to show full abstract
Microwave-assisted three-component reactions of arylglyoxals with cyclic 1,3-dicarbonyl compounds and naphthalen-2-amine have been established, by which a series of new functionalized benzo[e]indoles with good yields were synthesized. The reaction was easily conducted in HOAc, enabling domino cyclization to construct three new σ-bonds in a one-pot operation. Flexible structural modification and broad functional group compatibility as well as mild reaction conditions make this strategy a useful and attractive process of library generation for drug discovery.
Journal Title: Journal of Heterocyclic Chemistry
Year Published: 2017
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