Photo by techdailyca from unsplash
2-(1H-benzo[d]imidazol-2-yl)anilines reacted with haloketones including 5-chloropentan-2-one and 6-chlorohexan-2-one catalyzed by iodine, giving benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazoline and 6H-benzo[4,5]imidazo[1,2-c]pyrido[1,2-a]quinazoline derivatives, respectively. This domino-type reaction formed two new heterocycles and three new covalent bonds in… Click to show full abstract
2-(1H-benzo[d]imidazol-2-yl)anilines reacted with haloketones including 5-chloropentan-2-one and 6-chlorohexan-2-one catalyzed by iodine, giving benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazoline and 6H-benzo[4,5]imidazo[1,2-c]pyrido[1,2-a]quinazoline derivatives, respectively. This domino-type reaction formed two new heterocycles and three new covalent bonds in one-pot procedure and provided a green method for the synthesis of fused pentacyclic heterocycles bearing both quinazoline and benzimidazole moieties in ionic liquids.
Journal Title: Journal of Heterocyclic Chemistry
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!