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Hepatic Alanine Differentiates Nonalcoholic Steatohepatitis From Simple Steatosis in Humans and Mice: A Proton MR Spectroscopy Study With Long Echo Time

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To evaluate the hepatic metabolic alterations in nonalcoholic fatty liver disease (NAFLD) by using 1H‐MRS (proton magnetic resonance spectroscopy) with long echo time and to test the reproducibility of human… Click to show full abstract

To evaluate the hepatic metabolic alterations in nonalcoholic fatty liver disease (NAFLD) by using 1H‐MRS (proton magnetic resonance spectroscopy) with long echo time and to test the reproducibility of human study in an animal model. Liver biopsy is the gold standard for diagnosing NAFLD but with practical constraints. 1H‐MRS allows in vivo assessment of hepatocellular metabolism and has shown potential for biochemical differentiation in diffuse liver disease.

Keywords: long echo; study; proton; spectroscopy; echo time

Journal Title: Journal of Magnetic Resonance Imaging
Year Published: 2017

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