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Conventional and quantitative MRI in a novel feline model of demyelination and endogenous remyelination

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The feeding of irradiated food to healthy adult cats results in widespread, noninflammatory demyelination of the central nervous system (CNS); a return to a normal diet results in endogenous remyelination… Click to show full abstract

The feeding of irradiated food to healthy adult cats results in widespread, noninflammatory demyelination of the central nervous system (CNS); a return to a normal diet results in endogenous remyelination with functional recovery. This recently discovered, reversible disease might provide a compelling clinical neuroimaging model system for the development and testing of myelin‐directed MRI methods as well as future remyelination therapies.

Keywords: demyelination; model; conventional quantitative; quantitative mri; endogenous remyelination

Journal Title: Journal of Magnetic Resonance Imaging
Year Published: 2019

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