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According to the retrogenesis hypothesis, the rate of age‐related changes in white matter (WM) myelin content varies between early myelinating (parietal, occipital) and late myelinating (prefrontal, lateral–posterior temporal) areas. The… Click to show full abstract
According to the retrogenesis hypothesis, the rate of age‐related changes in white matter (WM) myelin content varies between early myelinating (parietal, occipital) and late myelinating (prefrontal, lateral–posterior temporal) areas. The multiecho spin echo (MESE), PD‐to‐T2‐weighted sequence provides an index of myelin content (myelin water fraction [MWF]) derived from measurements of myelin water (via the short T2 component [10–50 msec]) and intra‐ and extracellular water (via the long T2 component [>50–200 msec]).
Journal Title: Journal of Magnetic Resonance Imaging
Year Published: 2019
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