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Full‐length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan

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Full‐length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self‐limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates… Click to show full abstract

Full‐length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self‐limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates from each patient shared nucleotide identity of 99.97% in 7 225 nucleotides, and a phylogenetic analysis showed that they formed a cluster of Japanese isolates that is considered as a new HEV subtype 3k. The high similarity of HEV sequences of two isolates from these patients in this study suggested that a subtype 3k HEV strain had spread via a commonly distributed food in the city, possibly pig liver.

Keywords: full length; city; hepatitis; length genomic; hev; hepatitis virus

Journal Title: Journal of Medical Virology
Year Published: 2017

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