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Confirmatory molecular method for HTLV‐1/2 infection in high‐risk pregnant women

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Human T‐cell lymphotropic virus types 1/2 (HTLV‐1/2) are transmitted through sexual intercourse, transfusion of blood components, and vertical transmission, predominantly through breastfeeding. Six hundred forty‐three pregnant women from a high‐risk… Click to show full abstract

Human T‐cell lymphotropic virus types 1/2 (HTLV‐1/2) are transmitted through sexual intercourse, transfusion of blood components, and vertical transmission, predominantly through breastfeeding. Six hundred forty‐three pregnant women from a high‐risk prenatal care unit at a general hospital were tested by serological tests using chemiluminescence (CMIA) for screening, followed by a molecular confirmatory test. Four patients (0.6%) tested positive for HTLV‐1/2 by CMIA, two samples (0.3%) for each patient were confirmed as having HTLV‐1 or HTLV‐2 by PCR. The results show the importance of inclusion of HTLV‐1/2 screening for pregnant women in high‐risk prenatal care and the need for a molecular biological method to confirm HTLV‐1/2 infection.

Keywords: htlv; high risk; pregnant women; method; htlv infection

Journal Title: Journal of Medical Virology
Year Published: 2018

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