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Older adults with SARS‐CoV‐2 infection: Utility of the clinical frailty scale to predict mortality

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The objective of this study was to identify predictive factors of mortality in older adults with coronavirus disease 2019 (COVID‐19), including the level of clinical frailty by using the clinical… Click to show full abstract

The objective of this study was to identify predictive factors of mortality in older adults with coronavirus disease 2019 (COVID‐19), including the level of clinical frailty by using the clinical frailty scale (CFS). We analyzed medical records of all patients aged of 75 and older with a confirmed diagnosis of COVID‐19 hospitalized in our Hospital between March 3 and April 25, 2020. Standardized variables were prospectively collected, and standardized care were provided to all patients. One hundred and eighty‐six patients were included (mean 85.3 ± 5.78 year). The all cause 30‐day mortality was 30% (56/186). At admission, dead patients were more dyspneic (57% vs. 38%, p = .014), had more often an oxygen saturation less than 94% (70% vs. 47%, p < .01) and had more often a heart rate faster than 90/min (70% vs. 42%, p < .001). Mortality increased in parallel with CFS score (p = .051) (20 deaths (36%) in 7–9 category). In multivariate analysis, CFS score (odds ratio [OR] = 1.49; confidence interval [CI] 95%, 1.01–2.19; p = .046), age (OR = 1.15; CI 95%, 1.01–1.31; p = .034), and dyspnea (OR = 5.37; CI 95%, 1.33–21.68; p = .018) were associated with all‐cause 30‐day mortality. It is necessary to integrate the assessment of frailty to determine care management plan of older patients with COVID‐19, rather than the only restrictive criterion of age.

Keywords: frailty scale; mortality; frailty; clinical frailty; older adults

Journal Title: Journal of Medical Virology
Year Published: 2020

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