LAUSR

The efficacy of vaccination to prevent a huge widespread SARS-CoV2 infection is quite undoubtedly assessed by recent data and reports, yet the co-existence of naturally immunized (serum positive, SP) non-vaccinated people, SP vaccinated people and naïve (serum negative) people, should thoroughly revise our epidemiological overview and data interpretation about social contacts and even restriction measures. We are not merely talking about a blank immune population needing urgent vaccination but of a complex milieu of immunized subjects, whose thorough and expert knowledge may provide fundamental insights to improve the management of COVID-19 pandemic emergency. For example, upon vaccination, a good recommended practice is to evaluate both mucosal and serum immunity, by a quantitative salivary sIgAs and serum IgGs search, better if along a swab test, in order to group individuals called for vaccination in cohorts of susceptibility, which should enable physicians to take a decision about how many doses of vaccine and when, they should take into consideration, based on the previous immunity assessed from the subject. Actually, it seems that vaccines act quite exclusively as boosters This article is protected by copyright. All rights reserved.