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Does ACE2 mediate the detrimental effect of exposures related to COVID‐19 risk: A Mendelian randomization investigation

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Adiposity, smoking, and lower socioeconomic position (SEP) increase COVID‐19 risk while the association of vitamin D, blood pressure, and glycemic traits in COVID‐19 risk were less clear. Whether angiotensin‐converting enzyme… Click to show full abstract

Adiposity, smoking, and lower socioeconomic position (SEP) increase COVID‐19 risk while the association of vitamin D, blood pressure, and glycemic traits in COVID‐19 risk were less clear. Whether angiotensin‐converting enzyme 2 (ACE2), the key receptor for SARS‐CoV‐2, mediates these associations has not been investigated. We conducted a Mendelian randomization study to assess the role of these exposures in COVID‐19 and mediation by ACE2.

Keywords: mendelian randomization; risk; covid risk; ace2 mediate

Journal Title: Journal of Medical Virology
Year Published: 2022

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