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BACKGROUND Immunoglobulin G (IgG) antibodies against periodontal microorganisms can be markers of periodontal infection because their levels rise following infection and remain elevated several years later. METHODS We evaluated the relation between groups of IgG antibodies against 19 periodontal microorganisms and diabetes related mortality over 27 years among participants of the National Health and Nutrition Examination Survey III (1988 to 1992) 40 years and older at the time of examination (N = 8153). RESULTS Individuals in the highest versus lowest antibody tertiles were at 86% higher risk of dying due to diabetes related causes in the Red-Green antibody cluster (T. forsythia, T. denticola, A. actinomycetemcomitans, E. corrodens, S. noxia, V. parvula, C. rectus) (HR = 1.86, 95% CI 1.09 to 3.20) and 55% lower in the Orange-Blue antibody cluster (E. nodatum, A. naeslundii) (HR = 0.45, 95% CI 0.32 to 0.63) in multivariable models. In these models, individuals with diabetes at the time of examination had a 16-fold higher risk of dying due to diabetes related causes (HR = 16.4, 95% CI 11.0 to 24.7). CONCLUSION As a subset of periodontal microorganisms are associated with adverse systemic outcomes, antibody profiles may help in prediction of diabetes related mortality and identify sub-groups of individuals among whom periodontal treatment may impact diabetes related outcomes. This article is protected by copyright. All rights reserved.