LAUSR

BACKGROUND Urinary excretion of isoflavones and their metabolites after the consumption of soybean meal (SBM) and fermented soybean meal (FSBM) biscuits was investigated in humans in a randomized double-blinded crossover clinical trial. RESULTS Aglycones were the most abundant metabolites in urine in both treatments. After FSBM consumption, total aglycones and metabolites urinary excretion was 54% higher when compared to SBM biscuits. All metabolites were more rapidly excreted after FSBM biscuits consumption when compared to SBM biscuits. Urinary recovery of isoflavones was higher after FSBM biscuits consumption, reaching 67%. Women excreted higher amounts of colonic metabolites and lower amounts of aglycones than men. The prevalence of O-demethylangolensin-producers, equol-producers and nonproducers metabotypes was 56%, 11% and 36% after SBM consumption and 72%, 11% and 17% after FSBM consumption, respectively. CONCLUSION Together, our findings indicate that fermentation improves isoflavones bioavailability and possibly reduces the impact of gut microbiota on the metabolization of isoflavones. This article is protected by copyright. All rights reserved.