LAUSR

BACKGROUND Fruit juice is usually rich in monosaccharides and disaccharides. A reverse osmosis separation machine was used to remove monosaccharides and disaccharides from Hovenia dulcis fruit juice, leaving behind most of the bioactive substances in a low-sugar fruit juice (LSFJ), so as to provide a more effective treatment for diabetic patients. METHOD this study was carried out with type 1 diabetic mellitus (T1DM) model induced with high dose of streptozotocin (60 mg/kg), and oral administration of LSFJ for 4 weeks. RESULTS LSFJ treatment significantly gained body weight, and increased serum insulin level, IGF-1level, blood urea nitrogen (BUN) level, creatinine level, and hepatic glycogen level. Meanwhile, fasting blood glucose (FBG), fructosamine level, and glucose tolerance were also observably enhanced. Additional, LSFJ treatment significantly improved lipid metabolism, islet quality and islet oxidative stress. The mRNA levels of glucose metabolism genes in the pancreas of diabetic rats decreased in the DM group, while mRNA expression of these genes was significantly increased with LSFJ treatment. CONCLUSION These findings indicate that LSFJ can improve symptoms associated with T1DM. The research also suggests new strategies for diabetes prevention and treatment. This article is protected by copyright. All rights reserved.