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BACKGROUND Under the intensive modern poultry farming system, the lung of duck is one of the main targeted organs for various bacterial and viral infections. Curcumin is a kind of natural polyphenol compound which exist various beneficial biological functions including anti-inflammatory, antioxidant, and antiviral. The aim of this experiment was to investigated mechanism of Curcumin alleviated lipopolysaccharide (LPS) induced lung damages by Nrf2-ARE and NF-κB signaling pathway in ducks. RESULTS In total, 450 one-day-old male specific pathogen-free duck were randomly assigned into three dietary treatments: CON, basal diet; LPS, basal diet + LPS treatment; LPS+CUR, basal diet + LPS + 500 mg/ kg of Curcumin. At the end of experiment (21 days) ducks in LPS treatment were challenged with 5 mg LPS/kg of body weight and the other two treatments were injected with the same dose of phosphate-buffered solution. The results observed that LPS caused acute inflammation, oxidation stress, and lung injury. Dietary addition of Curcumin significantly relieved the oxidation stress and inflammation parameters. Moreover, results shown that remission may be through the signaling pathway of both Nrf2-ARE and NF-κB. CONCLUSION In conclusion, dietary supplementation of 500 mg/kg of Curcumin exhibited the lung protective effective in ducks. This experiment broadens the mode of metabolism actions of Curcumin in the target organs and provided an insight for the application of Curcumin in waterfowl feed. This article is protected by copyright. All rights reserved.