LAUSR

Dietary fiber (DF) is a carbohydrate from the edible part of plants and has the functions of promoting gastrointestinal motility, regulating gut microbiota (GM), and improving health. Lead (Pb) is a non-essential toxic heavy metal that can accumulate in the environment over time and enter the body through the respiratory tract, skin, and gastrointestinal tract. Lead not only causes disturbances in GM, but also leads to loss of homeostasis of immune functions, causes neuronal damage and results in neuroinflammation. Scientific literature reported that DF had anti-inflammatory activity as a natural product. This review highlights the role of DF and its metabolic products in alleviating lead-induced neuroinflammation by inducing changes in the species and quantity of GM and regulating the immune system, providing a potential dietary protective strategy for lead-induced disease. This article is protected by copyright. All rights reserved.