LAUSR

BACKGROUND The residues of sulfonamides in foods of animal origin are the potential risks to the consumer health, so it is very important to inspect their residues. Among the previously reported instrumental methods, the best method can only be used to determine at most 22 sulfonamides. So an instrumental method capable of determining more sulfonamides species is desirable. RESULTS In this study, sulfadoxine was used as template to synthesize a type of magnetic molecularly imprinted polymer that could recognize 35 sulfonamides. After characterization, this composite was used to develop a dispersive solid phase extraction method for extraction and purification of the 35 sulfonamides in pork followed by determination with an ultra performance liquid chromatography photodiode array method. This composite exhibited high adsorption capacity (11.01-19.21 μg/mg) and high recovery (>89.01%), and could be reused for at least 10 times. Due to the enrichment effect during sample preparation (enrichment factor 22-66), the limits of detection for determination of the 35 drugs in pork were in the range of 0.08-0.53 ng/g. The detection results for some real pork samples were consistent with a liquid chromatography tandem mass spectrometry method. After comparison, the present method showed generally better performances than the previously reported sample preparation methods and instrumental methods for detection of sulfonamides. CONCLUSIOIN Therefore, the method developed in the present study could be used as a practical tool for routine detection of sulfonamides residues in pork samples. This article is protected by copyright. All rights reserved.