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A total of 71 cases of colorectal carcinoma with hepatic metastasis were enrolled from the Department of Pathology of SIR RUN RUN SHAW Hospital. Paired primary tumors, hepatic metastases, and… Click to show full abstract
A total of 71 cases of colorectal carcinoma with hepatic metastasis were enrolled from the Department of Pathology of SIR RUN RUN SHAW Hospital. Paired primary tumors, hepatic metastases, and normal mucosa samples were collected from formalin‐fixed paraffin‐embedded tissues by manual macrodissection. And global levels of DNA methylation and hydroxymethylation in these tissues, measured by an ELISA‐like microplate‐based colorimetric methods. The immunohistochemical expression of 5‐methylcytosine and 5‐hydroxymethylcytosine were analyzed also.
Journal Title: Journal of Surgical Oncology
Year Published: 2018
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