LAUSR

To The Editor, I wish to congratulate Krishnan and colleagues for their article in which they investigated analyzed local recurrence (LR) rate and factors associated with LR in patients undergoing surgery for bonemetastasis. The most common primary cancers in the study group were lung cancer (n = 73, 24%), hepatocellular carcinoma (n = 68, 23%), renal cell carcinoma (n = 51, 17%), and breast cancer (n = 35, 11%). The authors reported that primary cancers of breast or prostate (HR = 0.391, P = 0.049) were independent factors associated with longer LR-free survival. The authors did not define subtypes of 35 breast cancer cases. HR-positive breast cancers (luminal A or B tumors) tend to relapse later and preferentially disseminate to the bone in comparison with HR negative breast cancers (HER-2+ and triple negative cases). Generally metastatic HR-positive tumors tend to have better outcome compared to HR-negative ones, especially if only solitary bonemetastasis exists. In the light of aforementioned information, breast cancer subtypes may affect LR in breast cancer group and might be taken into consideration. ORCID