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Gastric cancer (GC) with microsatellite instability (MSI) is a less aggressive disease and associated with resistance to 5‐fluorouracil (5‐FU)‐based chemotherapy (CMT). Thymidylate synthase (TS) is inhibited by 5‐FU, and another… Click to show full abstract
Gastric cancer (GC) with microsatellite instability (MSI) is a less aggressive disease and associated with resistance to 5‐fluorouracil (5‐FU)‐based chemotherapy (CMT). Thymidylate synthase (TS) is inhibited by 5‐FU, and another potential mediator of therapeutic resistance to 5‐FU. Therefore, we aimed to analyze the association between MSI and TS expression in GC, and its impact on disease outcomes.
Keywords:
cancer microsatellite;
microsatellite instability;
thymidylate synthase;
gastric cancer
Journal Title: Journal of Surgical Oncology
Year Published: 2022
Link to full text (if available)
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Journal Title: Journal of Surgical Oncology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!