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Sclerostin immunohistochemical staining in surgically treated giant cell tumor of bone

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Giant cell tumor of bone (GCTB) is a destructive lesion with a high potential for recurrence. RANK‐ligand targeted therapy has provided promising, yet mixed results. Sclerostin (SOST) inhibition results in… Click to show full abstract

Giant cell tumor of bone (GCTB) is a destructive lesion with a high potential for recurrence. RANK‐ligand targeted therapy has provided promising, yet mixed results. Sclerostin (SOST) inhibition results in a net anabolic response and is currently used in the treatment of osteoporosis. The application to GCTB is unknown.

Keywords: cell tumor; tumor bone; giant cell

Journal Title: Journal of Surgical Oncology
Year Published: 2022

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